Antibody responses to individual proteins of SARS coronavirus and their neutralization activities
Identifieur interne : 004E75 ( Main/Exploration ); précédent : 004E74; suivant : 004E76Antibody responses to individual proteins of SARS coronavirus and their neutralization activities
Auteurs : MAOFENG QIU [République populaire de Chine] ; YULING SHI [République populaire de Chine] ; ZHAOBIAO GUO [République populaire de Chine] ; ZELIANG CHEN [République populaire de Chine] ; RONGQIAO HE [République populaire de Chine] ; RUNSHENG CHEN [République populaire de Chine] ; DONGSHENG ZHOU [République populaire de Chine] ; ERHEI DAI [République populaire de Chine] ; XIAOYI WANG [République populaire de Chine] ; BINGYIN SI [République populaire de Chine] ; YAJUN SONG [République populaire de Chine] ; JINGXIANG LI [République populaire de Chine] ; LING YANG [République populaire de Chine] ; JIN WANG [République populaire de Chine] ; HONGXIA WANG [République populaire de Chine] ; XIN PANG [République populaire de Chine] ; JUNHUI ZHAI [République populaire de Chine] ; ZONGMIN DU [République populaire de Chine] ; YING LIU [République populaire de Chine] ; YONG ZHANG [République populaire de Chine] ; LINHAI LI [République populaire de Chine] ; JIAN WANG [République populaire de Chine] ; BING SUN [République populaire de Chine] ; RUIFU YANG [République populaire de Chine]Source :
- Microbes and infection [ 1286-4579 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
A novel coronavirus, the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), was identified as the causative agent of SARS. The profile of specific antibodies to individual proteins of the virus is critical to the development of vaccine and diagnostic tools. In this study, 13 recombinant proteins associated with four structural proteins (S, E, M and N) and five putative uncharacterized proteins (3a, 3b, 6, 7a and 9b) of the SARS-CoV were prepared and used for screening and monitoring their specific IgG antibodies in SARS patient sera by protein microarray. Antibodies to proteins S, 3a, N and 9b were detected in the sera from convalescent-phase SARS patients, whereas those to proteins E, M, 3b, 6 and 7a were undetected. In the detectable specific antibodies, anti-S and anti-N were dominant and could persist in the sera of SARS patients until week 30. Among the rabbit antisera to recombinant proteins S3, N, 3a and 9b, only anti-S3 serum showed significant neutralizing activity to the SARS-CoV infection in Vero E6 cells. The results suggest (1) that anti-S and anti-N antibodies are diagnostic markers and in particular that S3 is immunogenic and therefore is a good candidate as a subunit vaccine antigen; and (2) that, from a virus structure viewpoint, the presence in some human sera of antibodies reacting with two recombinant polypeptides, 3a and 9b, supports the hypothesis that they are synthesized during the virus cycle.
Affiliations:
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type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zeliang Chen" sort="Zeliang Chen" uniqKey="Zeliang Chen" last="Zeliang Chen">ZELIANG CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Rongqiao He" sort="Rongqiao He" uniqKey="Rongqiao He" last="Rongqiao He">RONGQIAO HE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratory of Visual Information Processing, Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Runsheng Chen" sort="Runsheng Chen" uniqKey="Runsheng Chen" last="Runsheng Chen">RUNSHENG CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dongsheng Zhou" sort="Dongsheng Zhou" uniqKey="Dongsheng Zhou" last="Dongsheng Zhou">DONGSHENG ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai 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Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xiaoyi Wang" sort="Xiaoyi Wang" uniqKey="Xiaoyi Wang" last="Xiaoyi Wang">XIAOYI WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bingyin Si" sort="Bingyin Si" uniqKey="Bingyin Si" last="Bingyin Si">BINGYIN SI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yajun Song" sort="Yajun Song" uniqKey="Yajun Song" last="Yajun Song">YAJUN SONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 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Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin Wang" sort="Jin Wang" uniqKey="Jin Wang" last="Jin Wang">JIN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hongxia Wang" sort="Hongxia Wang" uniqKey="Hongxia Wang" last="Hongxia Wang">HONGXIA WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xin Pang" sort="Xin Pang" uniqKey="Xin Pang" last="Xin Pang">XIN PANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Junhui Zhai" sort="Junhui Zhai" uniqKey="Junhui Zhai" last="Junhui Zhai">JUNHUI ZHAI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zongmin Du" sort="Zongmin Du" uniqKey="Zongmin Du" last="Zongmin Du">ZONGMIN DU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ying Liu" sort="Ying Liu" uniqKey="Ying Liu" last="Ying Liu">YING LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratory of Visual Information Processing, Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yong Zhang" sort="Yong Zhang" uniqKey="Yong Zhang" last="Yong Zhang">YONG ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Linhai Li" sort="Linhai Li" uniqKey="Linhai Li" last="Linhai Li">LINHAI LI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Guangzhou General Hospital of Guangzhou Command of PLA</s1><s2>Guangzhou 510010</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Jian Wang" sort="Jian Wang" uniqKey="Jian Wang" last="Jian Wang">JIAN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1><s2>Beijing 101300</s2><s3>CHN</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bing Sun" sort="Bing Sun" uniqKey="Bing Sun" last="Bing Sun">BING SUN</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences</s1><s2>Shanghai 200031</s2><s3>CHN</s3><sZ>23 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Ruifu Yang" sort="Ruifu Yang" uniqKey="Ruifu Yang" last="Ruifu Yang">RUIFU YANG</name><affiliation wicri:level="1"><inist:fA14 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wicri:step="Checkpoint">000706</idno><idno type="wicri:doubleKey">1286-4579:2005:Maofeng Qiu:antibody:responses:to</idno><idno type="wicri:Area/Main/Merge">005226</idno><idno type="wicri:Area/Main/Curation">004E75</idno><idno type="wicri:Area/Main/Exploration">004E75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antibody responses to individual proteins of SARS coronavirus and their neutralization activities</title><author><name sortKey="Maofeng Qiu" sort="Maofeng Qiu" uniqKey="Maofeng Qiu" last="Maofeng Qiu">MAOFENG QIU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yuling Shi" sort="Yuling Shi" uniqKey="Yuling Shi" last="Yuling Shi">YULING SHI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Guangzhou General Hospital of Guangzhou Command of PLA</s1><s2>Guangzhou 510010</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhaobiao Guo" sort="Zhaobiao Guo" uniqKey="Zhaobiao Guo" last="Zhaobiao Guo">ZHAOBIAO GUO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zeliang Chen" sort="Zeliang Chen" uniqKey="Zeliang Chen" last="Zeliang Chen">ZELIANG CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Rongqiao He" sort="Rongqiao He" uniqKey="Rongqiao He" last="Rongqiao He">RONGQIAO HE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratory of Visual Information Processing, Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Runsheng Chen" sort="Runsheng Chen" uniqKey="Runsheng Chen" last="Runsheng Chen">RUNSHENG CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dongsheng Zhou" sort="Dongsheng Zhou" uniqKey="Dongsheng Zhou" last="Dongsheng Zhou">DONGSHENG ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Erhei Dai" sort="Erhei Dai" uniqKey="Erhei Dai" last="Erhei Dai">ERHEI DAI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xiaoyi Wang" sort="Xiaoyi Wang" uniqKey="Xiaoyi Wang" last="Xiaoyi Wang">XIAOYI WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bingyin Si" sort="Bingyin Si" uniqKey="Bingyin Si" last="Bingyin Si">BINGYIN SI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yajun Song" sort="Yajun Song" uniqKey="Yajun Song" last="Yajun Song">YAJUN SONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jingxiang Li" sort="Jingxiang Li" uniqKey="Jingxiang Li" last="Jingxiang Li">JINGXIANG LI</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1><s2>Beijing 101300</s2><s3>CHN</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ling Yang" sort="Ling Yang" uniqKey="Ling Yang" last="Ling Yang">LING YANG</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1><s2>Beijing 101300</s2><s3>CHN</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin Wang" sort="Jin Wang" uniqKey="Jin Wang" last="Jin Wang">JIN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hongxia Wang" sort="Hongxia Wang" uniqKey="Hongxia Wang" last="Hongxia Wang">HONGXIA WANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xin Pang" sort="Xin Pang" uniqKey="Xin Pang" last="Xin Pang">XIN PANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Junhui Zhai" sort="Junhui Zhai" uniqKey="Junhui Zhai" last="Junhui Zhai">JUNHUI ZHAI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zongmin Du" sort="Zongmin Du" uniqKey="Zongmin Du" last="Zongmin Du">ZONGMIN DU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ying Liu" sort="Ying Liu" uniqKey="Ying Liu" last="Ying Liu">YING LIU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratory of Visual Information Processing, Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yong Zhang" sort="Yong Zhang" uniqKey="Yong Zhang" last="Yong Zhang">YONG ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Biophysics, Chinese Academy of Sciences</s1><s2>Beijing 100101</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Linhai Li" sort="Linhai Li" uniqKey="Linhai Li" last="Linhai Li">LINHAI LI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Guangzhou General Hospital of Guangzhou Command of PLA</s1><s2>Guangzhou 510010</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Jian Wang" sort="Jian Wang" uniqKey="Jian Wang" last="Jian Wang">JIAN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1><s2>Beijing 101300</s2><s3>CHN</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bing Sun" sort="Bing Sun" uniqKey="Bing Sun" last="Bing Sun">BING SUN</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences</s1><s2>Shanghai 200031</s2><s3>CHN</s3><sZ>23 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Ruifu Yang" sort="Ruifu Yang" uniqKey="Ruifu Yang" last="Ruifu Yang">RUIFU YANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20, Dongdajie</s1><s2>Fengtai District, Beijing 100071</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Microbes and infection</title><title level="j" type="abbreviated">Microbes infect.</title><idno type="ISSN">1286-4579</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Microbes and infection</title><title level="j" type="abbreviated">Microbes infect.</title><idno type="ISSN">1286-4579</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humoral immunity</term><term>Immune response</term><term>Neutralization</term><term>Neutralizing antibody</term><term>Recombinant protein</term><term>Severe acute respiratory syndrome virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term><term>Immunité humorale</term><term>Réponse immune</term><term>Protéine recombinante</term><term>Neutralisation</term><term>Anticorps neutralisant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel coronavirus, the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), was identified as the causative agent of SARS. The profile of specific antibodies to individual proteins of the virus is critical to the development of vaccine and diagnostic tools. In this study, 13 recombinant proteins associated with four structural proteins (S, E, M and N) and five putative uncharacterized proteins (3a, 3b, 6, 7a and 9b) of the SARS-CoV were prepared and used for screening and monitoring their specific IgG antibodies in SARS patient sera by protein microarray. Antibodies to proteins S, 3a, N and 9b were detected in the sera from convalescent-phase SARS patients, whereas those to proteins E, M, 3b, 6 and 7a were undetected. In the detectable specific antibodies, anti-S and anti-N were dominant and could persist in the sera of SARS patients until week 30. Among the rabbit antisera to recombinant proteins S3, N, 3a and 9b, only anti-S3 serum showed significant neutralizing activity to the SARS-CoV infection in Vero E6 cells. The results suggest (1) that anti-S and anti-N antibodies are diagnostic markers and in particular that S3 is immunogenic and therefore is a good candidate as a subunit vaccine antigen; and (2) that, from a virus structure viewpoint, the presence in some human sera of antibodies reacting with two recombinant polypeptides, 3a and 9b, supports the hypothesis that they are synthesized during the virus cycle.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Maofeng Qiu" sort="Maofeng Qiu" uniqKey="Maofeng Qiu" last="Maofeng Qiu">MAOFENG QIU</name></noRegion><name sortKey="Bing Sun" sort="Bing Sun" uniqKey="Bing Sun" last="Bing Sun">BING SUN</name><name sortKey="Bingyin Si" sort="Bingyin Si" uniqKey="Bingyin Si" last="Bingyin Si">BINGYIN SI</name><name sortKey="Dongsheng Zhou" sort="Dongsheng Zhou" uniqKey="Dongsheng Zhou" last="Dongsheng Zhou">DONGSHENG ZHOU</name><name sortKey="Erhei Dai" sort="Erhei Dai" uniqKey="Erhei Dai" last="Erhei Dai">ERHEI DAI</name><name sortKey="Hongxia Wang" sort="Hongxia Wang" uniqKey="Hongxia Wang" last="Hongxia Wang">HONGXIA WANG</name><name sortKey="Jian Wang" sort="Jian Wang" uniqKey="Jian Wang" last="Jian Wang">JIAN WANG</name><name sortKey="Jin Wang" sort="Jin Wang" uniqKey="Jin Wang" last="Jin Wang">JIN WANG</name><name sortKey="Jingxiang Li" sort="Jingxiang Li" uniqKey="Jingxiang Li" last="Jingxiang Li">JINGXIANG LI</name><name sortKey="Junhui Zhai" sort="Junhui Zhai" uniqKey="Junhui Zhai" last="Junhui Zhai">JUNHUI ZHAI</name><name sortKey="Ling Yang" sort="Ling Yang" uniqKey="Ling Yang" last="Ling Yang">LING YANG</name><name sortKey="Linhai Li" sort="Linhai Li" uniqKey="Linhai Li" last="Linhai Li">LINHAI LI</name><name sortKey="Rongqiao He" sort="Rongqiao He" uniqKey="Rongqiao He" last="Rongqiao He">RONGQIAO HE</name><name sortKey="Ruifu Yang" sort="Ruifu Yang" uniqKey="Ruifu Yang" last="Ruifu Yang">RUIFU YANG</name><name sortKey="Runsheng Chen" sort="Runsheng Chen" uniqKey="Runsheng Chen" last="Runsheng Chen">RUNSHENG CHEN</name><name sortKey="Xiaoyi Wang" sort="Xiaoyi Wang" uniqKey="Xiaoyi Wang" last="Xiaoyi Wang">XIAOYI WANG</name><name sortKey="Xin Pang" sort="Xin Pang" uniqKey="Xin Pang" last="Xin Pang">XIN PANG</name><name sortKey="Yajun Song" sort="Yajun Song" uniqKey="Yajun Song" last="Yajun Song">YAJUN SONG</name><name sortKey="Ying Liu" sort="Ying Liu" uniqKey="Ying Liu" last="Ying Liu">YING LIU</name><name sortKey="Yong Zhang" sort="Yong Zhang" uniqKey="Yong Zhang" last="Yong Zhang">YONG ZHANG</name><name sortKey="Yuling Shi" sort="Yuling Shi" uniqKey="Yuling Shi" last="Yuling Shi">YULING SHI</name><name sortKey="Zeliang Chen" sort="Zeliang Chen" uniqKey="Zeliang Chen" last="Zeliang Chen">ZELIANG CHEN</name><name sortKey="Zhaobiao Guo" sort="Zhaobiao Guo" uniqKey="Zhaobiao Guo" last="Zhaobiao Guo">ZHAOBIAO GUO</name><name sortKey="Zongmin Du" sort="Zongmin Du" uniqKey="Zongmin Du" last="Zongmin Du">ZONGMIN DU</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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